He was the son of Louis Casimir of Hohenlohe-Waldenburg, who styled himself Count of Neuenstein, Langenburg, Weikersheim, Künzelsau, Kirchberg and Ingelfingen and his wife, Anna of Solms-Lich.
Two of his brothers, Philip and Albert had served in the Nassau's army in 1572.
The new palace was designed by the Dutch architect Georg Robin.
It was located in the Weikersheim part of the County of Hohenlohe, which Wolfgang had received when the county was divided after his father's death.
In 1567, Wolfgang married Magdalena of Nassau-Dillenburg, a younger sister of William the Silent.