Covering a period of 60 years, the Sisters of Saint Francis of Rochester, Minnesota worked in conjunction with the Mayo family to open a hospital that would accept patients of all faiths.

Beginning with a 27-bed facility, the women physicians and other medical professionals would eventually serve in theaters of war, and create an environment that evolved according to patient needs.

The Mayo family and the Sisters of St. Francis worked conjointly to establish a facility open to all without regard to religious affiliation.

[4] Sisters Sienna Otto, Constantine Koupal, Fidelis Cashion, Hyacinth Quinlan, Fabian Halloran, and Sylvester Burke attended to the needs of the patients 24/7, doing double duty as surgical assistants.

Dr. Isabella Coler Herb of the Augustana Hospital in Chicago was brought in to organize the pathology department in 1899, the first female specialist in her field.

Put in charge of new acquisitions, and preserving papers written by the Mayo doctors, she taught the staff in research practices, and presentation methods.

[8] Mabel Root became part of the team in 1907, organizing the system for physician records keeping, adding color coding and number assignment to facilitate ease of use.

St. Mary's Nursing School graduate Florence Church Bullard (1880–1967) joined the Red Cross,[9] and was assigned to Evacuation Hospital 13.

Continuing there through 1919, Bullard was the first American woman to be recognized by the French government for bravery, receiving the Croix de guerre and bronze star.

With support from the Mayo, Bundy and nursing student Isabella Gooding set up their practice at the Colonial Hospital.

Services such as a lending library, financial assistance, occupational therapy, and a language interpreter were considered part of the holistic healing of the patient.

United States Army medical corp veteran Mary Foley worked at the diet kitchen at the Kahler Corporation, when she became acquainted with Dr. Will Mayo.

A young aspiring writer and 7th grade student when she read the book, created a board game about the individual women.