Depot Square was the central filming location for Hachi: A Dog's Tale in 2009.

The Blackstone Valley Tourism Council organizes a Polar Express excursion each year which operates from Woonsocket Depot.

The BSRC planned to build a high-level platform on the western side of the station for accessible level boarding.

[4] The Blackstone River Valley National Heritage Corridor office was relocated from the depot to a mill in Whitinsville, Massachusetts.

After a legal battle and settlement, the company agreed in December 2020 to vacate the building in January 2021.