Wooster High School has 25 athletic teams, of which 12 are for boys, 12 are for girls, and 1 is Co-Ed which compete in the Ohio Cardinal Conference of the Ohio High School Athletic Association.

[5] The Wooster High School Speech and Debate team was crowned state champions by the OHSSL in 2001, 2002, 2006 and 2015.

Wooster is the first school district in the state of Ohio to launch an inter-scholastic adaptive sports team for students with physical disabilities.

The team was crowned state champions in 2017, 2018 and 2019 with a combined all-time record of 54–0.

Wooster produced the first interscholastic wheelchair basketball player in Ohio to play the sport at the D1 college level.