The scope of their collection ranges from colonial to twentieth-century, encompassing manuscripts, textiles, paintings, and ceramics.

[4] The museum is made up of permanent and temporary exhibits, a research library, and currently owns and operates the local Salisbury Mansion.

[3] There is one permanent exhibit at the museum in the Fuller Gallery of Industrial History, entitled "In Their Shirtsleeves."

Dealing with a time period spanning over a century, the collection highlights the accomplishment of Worcester locals and the impact their inventions had on the area and beyond.

[10][11] The museum has highlighted the history of Worcester's diverse population through many exhibitions over the past 40 years.