The show is centered on fitness trainers and models located in the many cities of California.

The first three seasons featured many of the trainers who work for fitness trainer Jackie Warner, and some other aspects of the gym and its clients as well as Warner's other fitness ventures, and private life.

In 2003, fitness expert Jackie Warner opened Sky Sport and Spa.

On July 19, 2006, the Bravo network aired the first episode of Work Out (developed following Jackie's appearance on Jonathan Antin's Bravo reality series Blow Out).

The show follows the day-to-day routine of Jackie and shows all of the drama that goes on behind the scenes in keeping a business afloat, while juggling her own personal life, as well as dealing with the personal issues of those who work for her as trainers.