The team reopens a brutal 1994 triple-murder case in which three young boys, 10-year-old best friends Jack Raymes, George Russo, and Sean Costley, were all murdered when the mother of one of the two teenagers convicted of the crime comes forward with evidence that they were innocent.
The team reinvestigates the 1953 case of Bingo Zohar, a talented 19-year-old rock'n'roll singer when new evidence comes forth suggesting he wasn't killed in the place where his body was found.
The team reopens the unsolved 1989 case of an unidentified Jane Doe, 30-year-old Margot Chambers, when she dies in the hospital after being comatose since the day she was shot 18 years ago, only to encounter a long list of suspects when they learn that the woman was a professional grifter who had swindled dozens of people and now have to solve which of her victims was the most motivated to kill her.
The team reopens the 1982 murder of Mike Delaney, a popular 22-year-old college valedictorian who was shot to death on the day of his graduation, after "RAPIST" is spraypainted onto his grave.
Lilly and Scotty travel to West Virginia to escort a suspected murderer who is believed to have abducted a woman, Brenda McDowell, from her 2007 engagement party and then killed her, back to Philadelphia.
The 1997 case of Pete Doyle, an 45-year-old ex-con who went missing after having been released from prison, is reinvestigated when the victim's decomposed severed hand is discovered in a crack house during a drug bust.
Priscilla Chapin, a former drug addict whose son, Max, was seemingly killed in an apartment fire in 2005 comes forth claiming she just saw her child in the park.