Worsley and Eccles South was a county constituency in Greater Manchester in the House of Commons of the Parliament of the United Kingdom.

[2] The constituency covered the western half of the City of Salford, mostly safe Labour territory, but the seat also contained two of the Conservatives' strongest wards in the relatively affluent areas of Worsley and Boothstown & Ellenbrook; these are also the only two Remain-voting wards in the constituency.

In the far south-west of the constituency along the ship canal were the villages of Irlam and Cadishead, separated from the other settlements by swathes of green belt land and farms in the form of Chat Moss, a protected peatland area.

In the 2019 general election, the BBC's exit poll forecast it as a Conservative gain, but it was not in fact among the many leave-supporting red wall seats to fall, and Labour held on although with a reduced, albeit comfortable, majority.

[4] Following council boundary changes that took effect in 2021,[5] the electoral wards included in the Worsley and Eccles South constituency are currently Barton & Winton, Boothstown and Ellenbrook, Cadishead & Lower Irlam, Higher Irlam & Peel Green Ward, Little Hulton, Walkden North, Walkden South, Worsley & Westwood Park.