In September 2004, Wouter Weylandt became a member of the team Quick-Step–Davitamon, participating in the Memorial Rik Van Steenbergen, Grote Prijs Jef Scherens and Circuit Franco-Belge, where he took twelfth place.

Towards the end of the season, he won the GP Briek Schotte, and finished fifth at the Memorial Rik Van Steenbergen event and the National Award, demonstrating his excellent sprinting qualities.

In 2006, his first full season, he finished fifth in the Three Days of West Flanders, then second in the Nokere Koerse, where he won the bunch sprint behind Bert Roesems.

During this season, he failed to achieve any victories, apart from the small GP Vichte, but showed great consistency in the sprint, in particular, winning the points classification of the Tour of Poland and finishing fifth in the Championship of Flanders.

He participated as lead-out rider for team leader Tom Boonen, but when he dropped out Weylandt seized his chance and won the 17th stage in Valladolid.

In stage 3 of the 2011 Giro d'Italia, Weylandt crashed while descending the Passo del Bocco [it], in the frazione Isola di Borgonovo, municipality of Mezzanego, suffering a fatal injury.

Weylandt lost control and hit the leading edge of a low concrete guard rail on the left side of the road with his foot and pedal.

[6] The medical chief of staff of the Giro, Dr. Tredici, was right behind the accident in a service car and reported that he ran to Weylandt less than 20 seconds after the crash but, he said on Sky News, "...he was already and clearly dead upon impact.

Upon their arrival, Weylandt was declared dead at the scene due to facial and basal skull fractures, as his injuries were too severe to allow resuscitation.

[14] In tribute to Weylandt, the following day's stage of the race was neutralized, with teams taking turns to ride in front, and all riders wearing black armbands.

A Bersaglieri band performed "Il Silenzio" at the beginning of the stage,[15] while supporters held up condolence messages and replicas of Weylandt's race number, 108, as a token of respect along the route.