The 2010 Scheldeprijs cycling race took place on 7 April 2010.

The peloton took on a high pace from the start, completing 50 kilometers during the first hour.

After 56 kilometres 8 cyclists formed a breakaway: Jonas Ljungblad (Omega Pharma–Lotto), Mathew Hayman (Team Sky), Jackson Stewart (BMC Racing Team), David Boucher (Landbouwkrediet), Arnoud van Groen (Vacansoleil), Cyril Lemoine (Saur–Sojasun), Gregory Joseph (Topsport Vlaanderen–Mercator) and Niko Eeckhout (An Post–Sean Kelly).

After 168 kilometres Jackson Stewart was dropped from the lead group and with 192 kilometres gone, only Mathew Hayman, Niko Eeckhout, Jonas Ljungblad, Arnoud van Groen and Cyril Lemoine were left although they were all caught just a few kilometres further.

It the end it turned out to become a bunch sprint, in which Tyler Farrar (Garmin-Transitions) was fastest by far.