The event aired via pay-per-view (PPV) and livestreaming and featured wrestlers from the promotion's Raw and SmackDown brand divisions.

In the main event for Night 1, Bianca Belair defeated Sasha Banks to win the SmackDown Women's Championship.

[8] "Save Your Tears" by The Weeknd, "Head Up High" by Fitz, and "All The Gold" by def rebel were the official theme songs for the event.

[20] In October 2020, it was reported by the Wrestling Observer Newsletter that WWE was relocating WrestleMania 37 to Raymond James Stadium in Tampa, Florida, as the state of the pandemic in California made it unlikely that the event could be held with in-person spectators on the originally scheduled date.

[22] Rival promotion All Elite Wrestling (AEW) held tapings with spectators at Jacksonville's Daily's Place since late August 2020 at 15% of the venue's capacity.

Mayor of Tampa Jane Castor stated that the event would be "in true WWE fashion, the perfect comeback story and marks a clear indication that our beautiful city is poised to bounce back stronger than ever."

Mayor of Inglewood James T. Butts Jr. welcomed WWE's decision to allow Tampa to "have their rightful WrestleMania moment".

[29] On March 17, the Tampa Bay Times confirmed that the capacity for each night would be 25,000 spectators and that attendees would be separated by pods with physical distancing in place.

[d] [46] The SmackDown Tag Team Championship was also defended on the episode in a fatal four-way match where Dolph Ziggler and Robert Roode retained.

The week was capped off by the Raw after WrestleMania on Monday April 12, and then finally, NXT began airing in its new Tuesday night slot.

[55] Over the next week, Edge appeared on Raw, NXT, and SmackDown, confronting each brand's world champion,[56][57][58] but stated he would wait until after Elimination Chamber to make his decision.

[63] On the March 26 episode of SmackDown, WWE official Adam Pearce scheduled Reigns to defend the Universal Championship against Bryan and Edge in a triple threat match at WrestleMania in the main event of Night 2.

Following the match, however McIntyre was brutally attacked by Bobby Lashley, allowing The Miz to cash-in his Money in the Bank contract and win the title.

[72] Incensed at being left out of Raw's Elimination Chamber match, Braun Strowman took issue with WWE officials Shane McMahon and Adam Pearce.

[56] Over the next few weeks, Miz and his tag team partner John Morrison continued to constantly taunt Bad Bunny.

[38] At TLC: Tables, Ladders & Chairs in December 2020, Randy Orton defeated "The Fiend" Bray Wyatt in a Firefly Inferno match.

[74] Following this incident, Alexa Bliss, who had aligned with The Fiend months earlier, began to haunt Orton on a weekly basis, including causing him to lose multiple matches.

The pre-show panel included host Kayla Braxton — joined by Jerry Lawler, Booker T, John "Bradshaw" Layfield, and Peter Rosenberg, as well as guest Sonya Deville.

[85] In the fourth match, The New Day (Kofi Kingston and Xavier Woods), who were introduced by former stablemate Big E, defended the Raw Tag Team Championship against AJ Styles and Omos.

[90] Next, Nia Jax and Shayna Baszler defended the WWE Women's Tag Team Championship against Natalya and Tamina.

[90] In the main event, Roman Reigns (accompanied by Paul Heyman and Jey Uso) defended the Universal Championship against Edge and Daniel Bryan.

[90] After The Fiend's loss against Randy Orton at the event, various personalities like UFC's Daniel Cormier,[91] John Cena Sr.,[92] Booker T,[93] Erick Rowan,[94] and Mark Madden[95] showed support to Bray Wyatt and criticized his booking treatment in WWE.

[2] WrestleMania 37 would be the final WWE appearance for Billie Kay, as well as Raw commentator Samoa Joe, as both were released on April 15.

[105] Because WrestleMania 37 had to be held in a reduced venue capacity, WWE went as far as to promote their next "Big Four" PPV, SummerSlam, as their "biggest event of 2021".

[109] This would in turn be Wyatt's final appearance in WWE until he returned at Extreme Rules in October 2022,[115] as after being absent for the next few months, he was released from his contract on July 31.

[114] On the following SmackDown, Universal Champion Roman Reigns, along with Paul Heyman and Jey Uso, boasted about retaining his championship over Edge and Daniel Bryan.

Later backstage, Cesaro confronted Adam Pearce and Sonya Deville about facing Reigns that night, even as a non-title match.

[121] On the May 7 episode of SmackDown, Cesaro faced and defeated Seth Rollins in a rematch to earn a Universal Championship match against Roman Reigns at WrestleMania Backlash.

[126] Edge was then granted a rematch for the Universal Championship at Money in the Bank, this time as a one-on-one match that he was originally supposed to have at WrestleMania.

[127] At the event, Reigns retained after interference from Seth Rollins, who lost the men's Money in the Bank ladder match earlier that night, and felt like Edge cut in line in front of him.