Presented and executively produced by Dreddy Krueger, the main production was handled by Bronze Nazareth, Preservation, Allah Mathematics, DJ Noize, Fred Ones and RZA.

It features contributions from several fellow independent hip-hop musicians, such as Byata, Del the Funky Homosapien, Ras Kass, Aesop Rock, Casual, C-Rayz Walz, Littles, MF Doom, Planet Asia, R.A. the Rugged Man, Roc Marciano, Sean Price, Sir Menelik, Tragedy Khadafi, Vast Aire and Vordul Mega among others, as well as narrations by Jim Jarmusch.

The album was supported with two singles: "Biochemical Equation" b/w "Preservation" and "Lyrical Swords" b/w "Think Differently".

The Lost Files version was released on July 15, 2009, combining songs and beats recorded around 2005 and 2006 for Wu-Tang Meets the Indie Culture but were left off.

The official follow-up album to Wu-Tang Meets the Indie Culture entitled Dreddy Kruger Presents...