Wu Han (died 44 CE), courtesy name Ziyan, was a Chinese military general and politician during the Eastern Han dynasty who made great contributions to Emperor Guangwu (Liu Xiu)'s reestablishment of the Han dynasty and who is commonly regarded as Emperor Guangwu's best general, but who was also known for cruelty against civilians.

Wu Han was initially a deputy to Peng Chong (彭寵), the governor of Yuyang Commandery (漁陽, roughly modern Beijing), during the brief reign of Gengshi Emperor.

After Liu declared himself emperor in 25, he made Wu the commander of the armed forces (大司馬, da sima) – one of the three most important officials in the imperial government.

A more salient example of Wu's cruelty, however, came in 36, when the Han forces, commanded by Wu, captured Chengdu, the capital of Gongsun Shu's separatist state Chengjia, to finally reunify the empire.

When Wu died in 44, Emperor Guangwu ordered that he be buried with the same honors given to the great Western Han statesman Huo Guang.