He then completed graduate studies in the United States, where he earned a master's degree and his Ph.D. in theoretical and applied mechanics from Cornell University in Ithaca, New York.

[1] After receiving his doctorate, Wu was a professor at the Institute of Applied Mechanics of National Taiwan University.

[4] He returned to public service as minister without portfolio specializing in technology-related policy upon the presidential inauguration of Tsai Ing-wen in 2016.

[5] From this position, Wu commented on several aspects of digital infrastructure,[6] including the implementation of 5G telecommunications[7][8] and the proliferation of fake news online.

[12][13] Wu succeeded Chen Liang-gee as minister of science and technology at the start of Tsai Ing-wen's second presidential term.