[1] In 2008, she appeared in Rough Crossings, directed by Rupert Goold and based on the book by Simon Schama, at the Lyric Hammersmith;[1] The Vertical Hour (2010),[1] by David Hare, and Truth and Reconciliation (2011),[1] both at the Royal Court Theatre.

In 2009, she starred in the BBC Two series Moses Jones, for which she won Best Actress in a Miniseries at the Rome Fiction Festival.

In 2010, Wunmi Mosaku was named one of The Seven Fresh Faces of Toronto International Film Festival, for I Am Slave,[9] in which she starred.

[6] In 2015, Mosaku played the part of Quentina, a traffic warden, in the three-part BBC series Capital based on John Lanchester's novel of the same name.

[11] When asked to list her personal heroes, Mosaku included her grandmother Anike Adisa, whom she described as having "taught me so many lessons"; actor Albert Finney, who was her inspiration for attending the RADA; her colleague and former instructor at RADA, William Gaskill; Paul Newman, whom she admired, not just for his acting, but also for his philanthropic efforts with Newman's Own; and Oprah Winfrey, who Mosaku considers "a superwoman".