The Wupper-Lippe-Express is an hourly Regional-Express service in German state of North Rhine-Westphalia, which forms part of the Rhine-Ruhr S-Bahn.

The line is operated by DB Regio NRW on behalf of the Verkehrsverbund Rhein-Ruhr (VRR).

Originally, the long-planned upgrade of the network would have meant that all cities in the Rhine-Ruhr metropolitan region were served by S-Bahn trains.

[4] The service only runs from Monday to Friday between 5 a.m. and 7 p.m. An extension of the operating times is planned at a later date.

[5] A 20-minute frequency is offered from Monday to Friday on the Wesel–Oberhausen section in combination with the Rhein-Express (RE 5 (RRX)) and the Rhein-IJssel-Express (RE 19) services.