Wyaconda is a city in Clark County, Missouri, United States.

Wyaconda is part of the Fort Madison–Keokuk, IA-MO Micropolitan Statistical Area.

[6] The Atchison, Topeka and Santa Fe Railroad passes through the community.

[7] According to the United States Census Bureau, the city has a total area of 0.64 square miles (1.66 km2), all land.

38.0% of all households were made up of individuals, and 16.6% had someone living alone who was 65 years of age or older.

Amtrak’s Southwest Chief, which operates between Los Angeles and Chicago, passes through the town on BNSF tracks, but makes no stop.

The nearest station is located in Fort Madison, 54 miles (87 km) to the northeast.