Wyeville is a village in Monroe County, Wisconsin, United States.

At this location, a branch rail line was constructed eastward to Necedah.

The local post office was called Wyeville when established in 1890 and the first postmaster was Charles Brooks.

[8][9] The name Wyeville is documented as a variation of "Wythe", a county in Virginia.

[11] The Milwaukee, Sparta, and Northwestern Railroad, a subsidiary of the Chicago and North Western Railway, began the "Air Line" or "Adams Cutoff" from Adams, Wisconsin towards Sparta, Wisconsin in 1910.

[11] Until 1963, passengers of Twin Cities 400 and the Rochester 400 changed trains there, as it was a scheduled transfer point for the two streamliners.

[13][14][15] According to the United States Census Bureau, the village has a total area of 0.59 square miles (1.53 km2), all of it land.

The racial makeup of the village was 93.84% White, 3.42% Native American, 2.74% from other races.