It was succeeded by the present-day Wyggeston and Queen Elizabeth I College.
After William Wyggeston's death in 1536, his brother Thomas Wyggeston, as a trustee, used part of the money to establish a school for boys known as the Elizabethan Grammar School.
This eventually became defunct in the 19th century, but was re-founded on the site of the old Wyggeston Hospital as the Wyggeston Hospital School, which took its first pupils on 30 April 1877.
In 1970/1971, the school won the national Top of the Form radio quiz show, beating Harris Academy, Dundee, in the final on 2 January 1971.
After the reorganisation of local government, the system of education in the City of Leicester became comprehensive, and the school closed in 1976 to be replaced by other schools, including the Wyggeston and Queen Elizabeth I College.