The once predominantly rural area has developed into a thriving suburban bedroom community as the city of Abilene expanded in the latter half of the 20th century.

Wylie is located approximately five miles southwest of downtown Abilene along FM 89 (Buffalo Gap Road) in the northeastern portion of Taylor County.

Wylie is part of the Abilene, Texas Metropolitan Statistical Area, which includes all of Taylor, Jones, and Callahan Counties.

Wylie's population has increased exponentially in the past several decades due to continued growth of the Abilene Metropolitan Statistical Area.

The fast-growing district also serves other portions of south Abilene, the unincorporated communities of Potosi, Caps, and View, and other predominantly rural areas of east central Taylor County.