[3] Following the establishment of Melbourne and the town of Werribee in the early 1800s, Wyndham Vale became a pastoral area with many hectares of land cleared for cattle and other farming.

[4] This remained until the late 1990s and early 2000s when the suburban development of the western suburbs of Melbourne began to rapidly expand.

[5][6] This growth increased rapidly after June 2012, when Victorian Planning Minister Matthew Guy announced an increase in Melbourne's growth boundary by 5858 hectares, including extending the boundary to encompass area of Wyndham Vale.

Wyndham Vale train station was opened on 21 June 2015 as part of the Regional Rail Link.

Electrification of the line up to Wyndham Vale was considered in design of Regional Rail Link, which has been announced by the Victorian Government to be completed by 2031.

[9] In 2015, coinciding with the opening of the Regional Rail Link, the Wyndham bus network was extensively upgraded.

It consists of several walking and cycling tracks, wetlands, dog off-leash areas and vegetation home to significant numbers of flora and fauna.