Highway 211 travels west from WYO 219, and immediately intersects exit 16 of Interstate 25.

At 3.8 miles, WYO 211 intersects Round Top Road, the former northern terminus of Wyoming Highway 222.

WYO 211 continues west and then northwest to serve the small outlying communities of Lambert, Iron Mountain, Federal, and Horse Creek.

[2] WYO 211 resumes north of the Laramie-Platte County Line along Iron Mountain Road and Jordan Road (County Route 106–2).

Now named Horse Creek Road, WYO 211 reaches the Town of Chugwater at 63.03 miles (101.44 km), and has a junction with I-25 / US 87 and Wyoming Highway 313 at 63.95 miles (102.92 km).