The portions that the bypass enters the city limits are between the railroad tracks and Ranchettes, and the northern terminus.

After that intersection, WYO 212 passes Laramie County Community College and turns northward toward Interstate 80.

WYO 212 intersects Fox Farm Road (former Wyoming Highway 221) at 5.1 miles (8.2 km) before heading north to an interchange with I-80.

Between the Interstate 80 interchange and US 30 (Lincolnway), Wyoming Highway 212 runs concurrent with Business Loop I-80.

WYO 212 then heads north and west around Cheyenne, taking on the name Four Mile Road.