Within the U.S. state of Wyoming, it runs from Kemmerer to Pine Bluffs by way of Rock Springs, Laramie, and Cheyenne.

Immediately after that junction, US 30 and WYO 89 leave the town and continue through dry, sandy plains with some farmland scattered on the sides.

Through here, the road largely parallels Cokeville Meadows National Wildlife Refuge as the two routes continue south.

The road turns entirely in a due west direction as US 30 and US 189 leave the city a mile (1.6 km) later at the intersection of Lincoln Street and Spring Valley Drive, and US 30 and US 189 enter rural areas.

The section of US 30 west of Kemmerer is planned to be rerouted to parallel the Union Pacific Railroad as part of a project to expand a nearby coal mine.

Entering Sweetwater County, the road intersects I-80 near Granger as it merges on to the Interstate for the first time, and the two are concurrent for a very long distance (169 miles (272 km)).

The three routes are concurrent for 20 miles (32 km) as they pass by Sinclair to intersect the eastern terminus of WYO 76.

They continue through Wilcox, Rock River, Lookout, and Bosler, before reaching Laramie, the next major city, and home to the University of Wyoming.

West of Cheyenne, the state capital, the routes pass by a large wind farm and follow a gap of bumpy hills in the area.

As I-80 Bus./US 30 enter the downtown area, they pass by numerous businesses, restaurants, and hotels lining the road.

They travel through Hillsdale and parallel the Union Pacific Railroad's Sidney Subdivision line.

[14] US 30 was established in 1926 as a replacement for the former Lincoln Highway, a transcontinental route connecting San Francisco, California, to Times Square in New York City.