At 6.21 miles (9.99 km), WYO 319 has an intersection with a local road which heads west to exit 104 off I-25/US 26/US 87.

Still heading north, WYO 319 enters Glendo from the south, intersecting A Street at 14.16 miles (22.79 km).

As WYO 319 leaves Glendo, at 15.4 miles (24.8 km), there is a road named Lake Shore Road that travels east of WYO 319 and allows access to Glendo State Park, one of Wyoming's most popular boating parks.

I-25/US 26/US 87 breaks its parallel and leaves to head more northwest towards Douglas, while WYO 319 turns north to come to an end at US 18/US 20 in Orin at 28.84 miles (46.41 km).

[3][4] WYO 319 is the original alignment of Old US 185 between 1926 and 1936[5] and US 87 (Yellowstone Highway) from 1936 until I-25 was completed (between 1956 and the 1980s) and therefore routed along it.