XHMNU-TV was one of the first university-run broadcast stations in Mexico, signing on channel 53 in June 1990 under the auspices of the School of Mechanical and Electrical Engineering at UANL.

Its transmitter was located on the third floor of the Center for Design and Maintenance of Instruments, and its signal only reached a radius of 3 kilometres (1.9 mi) from the site.

On September 24, 2003, XHMNU moved its transmitter and drastically increased its power to 500 kW to cover the entire Monterrey metropolitan area.

The next year, an agreement between UANL and Cablevisión Monterrey put channel 53 on cable in the city.

[3] With digital television, XHMNU briefly began using virtual channel 35 but returned to 53 in October 2016.