Xenbase is a Model Organism Database (MOD), providing informatics resources, as well as genomic and biological data on Xenopus frogs.

[3] Its virtual machines are running in a VMware vSphere environment on two servers, with automatic load balancing and fault tolerance.

This makes them a particularly attractive system for testing the ectopic activity of gene products and loss-of-function experiments using antagonizing reagents such as morpholinos, dominant-negatives and neomorphic proteins.

[4] Xenopus embryos develop very quickly and form a full set of differentiated tissues within days of fertilization, allowing rapid analysis of the effects of manipulating embryonic gene expression.

[6] Xenbase provides a large database of images illustrating the full genome, movies detailing embryogenesis, and multiple online tools useful for designing and conducting experiments using Xenopus.

Specifically, John Gurdon's experiments showed that a mature or differentiated cell nucleus can be returned to its immature undifferentiated form; this is the first instance of cloning of a vertebrate animal.

Goda et al., performed a large scale forward genetics screen on X. tropicalis embryos to identify novel mutations (2006).

The Xenopus Molecular Marker Resource page was used to design a microarray experiment which compared wild type (normal circulation) and "wha" mutant X. tropicalis.

Traditionally, antisense morpholino oligonucleotides have been the method of choice to study the effects of transient gene knockdown in Xenopus.