She starred in the first season of the Netflix comedy series The Baby-Sitters Club (2020), and gained wider recognition for playing America Chavez in the Marvel Cinematic Universe film Doctor Strange in the Multiverse of Madness (2022).

[3][4] Both of her parents are of Mexican descent; her mother is a set decorator for feature films, while her father is a construction worker from Morelos.

[9] Jennifer Lawrence's performance as Katniss Everdeen in The Hunger Games film series inspired her to pursue a professional acting career.

"[18] In March 2021, Netflix recast her role for the show's second season due to scheduling conflicts with Gomez filming Doctor Strange in the Multiverse of Madness (2022).

Gomez did martial arts, kickboxing, and stunt training for "every other day for hours", hoping to "blow [the casting directors'] minds" in a potential callback.

[13] Six months after her initial audition, Gomez received a callback and did a screen test with Stephen Strange actor Benedict Cumberbatch.

[24] Aged 16 at the time of Doctor Strange in the Multiverse of Madness's release, Gomez was one of the youngest actors to portray a superhero in the Marvel Cinematic Universe.

[30] In August 2022, she was cast in the science fiction thriller film Ursa Major alongside Mary Elizabeth Winstead.

[32] On the December 5 season finale, Gomez and Chmerkovskiy won first place and were awarded the inaugural Len Goodman Mirrorball Trophy.