The oldest line of Yōshin-ryū (楊心流) is probably the school founded by Nakamura Sakyōdayū Yoshikuni around 1610, and is often referred to as Yōshin Koryū (楊心古流).
This line has a historical connection to the Takeda family through the founder's grandfather, Nakamura Yorifusa.
Yorifusa was a retainer of the Koshu Takeda who founded a school of jujutsu called Taiyo ryu.
Yoshin Koryu was founded by Nakamura Yoshikuni in Nagasaki after being driven from Takeda lands by Tokugawa Ieyasu.
This school was reportedly influenced by the Chinese martial artist and scholar, Chin Genpin.