Jagan Mohan Reddy started his political career in the Indian National Congress and was elected as the Member of Parliament of Kadapa in 2009.

[13] After his father's death due to a helicopter crash in 2009, he started an Odarpu Yatra (a consoling tour) across the state.

CBI summoned Reddy for allegedly amassing huge assets through illegal means by using his father's office while he was the chief minister.

CBI and ED has also summoned 58 companies of investing in Reddy's businesses, for the favours they allegedly received in the form of mining leases, allotments of projects.

[27] His party suffered severe anti-incumbency and defeat in the 2024 Andhra Pradesh legislative assembly election slumping down to a meagre 11 seats from 151 in 2019.

The Congress party's central leadership directed him to call off his odarpu yatra, an order which he defied leading to a fallout between the high command and himself.

[44] Reddy, as the president of YSR Congress, faced by-election from the Kadapa constituency and won by a large margin of 545,043 votes.

[47] As a leader of the Opposition in Assembly and YSR Congress Party's president, Reddy launched his 3,000-km-long walkathon named Praja Sankalpa Yatra, popularly called padayatra, on 6 November 2017 at Idupulapaya in Kadapa district.

Reddy while boarding a flight to Hyderabad was attacked with a cock fighting knife in the VIP Lounge of Visakhapatnam Airport on 25 October 2018.

[54] Jagananna Amma Vodi provides financial assistance for mothers or guardians from the Below Poverty Line, to educate their children.

[55][56] Navaratnalu is a collection of nine welfare schemes covering farmers, women, medical and health, education and Special Category Status.

[59] As of April 2023, it was reported by the Association for Democratic Reforms that he was the richest Chief Minister in India, with total assets of 510 crore.

[63][64] On 12 July 2024, Jagan along with two senior IPS officers and two retired officials, were booked in an attempt to murder case, following a complaint lodged by TDP Undi MLA K Raghuram Krishna Raju.

[67][68] While in jail, Reddy started a hunger strike opposing the United Progressive Alliance's decision to endorse the creation of a separate Telangana state.