Yagnelis Mestre (born October 24, 1983, in Havana) is a Cuban judoka, who played for the half-middleweight category.

[1] She won a bronze medal for the 57 kg class at the 2007 Pan American Games in Rio de Janeiro, Brazil.

[2] Mestre represented Cuba at the 2008 Summer Olympics in Beijing, where she competed for the women's half-lightweight class (52 kg).

She lost the first preliminary match to North Korea's An Kum-Ae, who scored a waza-ari-awasete-ippon before the start of the second minute.

[3] Because her opponent advanced further into the final match against China's Xian Dongmei, Mestre offered another shot for a bronze medal through the repechage, where she was defeated by Venezuela's Flor Velázquez, who only scored a single koka within a five-minute period.