Yamaguchi Sekkei (Japanese: 山口雪渓) also known as Yamaguchi Sōsetsu (山口宗雪) (1644/48, Kyoto - 22 October 1732, Kyoto) was a Japanese artist of the middle Edo period.
Although his year of birth is generally considered to be 1644, documents at Kiyomizu-dera suggest that it may have been 1648 or even 1649.
It has been said that he was a great admirer of the artists Muqi (Chinese:牧谿) or "Mokkei" in Japanese, and Sesshū (雪舟) and that he created his art name by combining characters from both of their names.
Among his best known works are a pair of screens depicting "Autumnal Maples" in Daigo-ji, which were shown in Berlin in 1939 as part of the Exhibition of Japanese Art [de].
They comprise fifteen landscapes with figures, sixteen scenes with flowers and birds and twelve portraits of Buddhist saints.