Mercado made her professional debut on 19 July 2014, scoring a first-round unanimous decision (UD) victory over Yoatzin Meraz at the Gimnasio Municipal in Nuevo Casas Grandes, Mexico.
[8] She had two wins over Diana Gutierrez in 2016–a third-round TKO in March[9] and a six-round UD in an August rematch[10]–before going on to fight Jessica Munoz for the vacant WBC FECOMBOX female super bantamweight title.
[11] Mercado bounced back with two more wins at the end of 2017; a UD against Milagros Diaz in November[12] and a corner retirement (RTD) victory over Juana Felix in December.
[16] Her final fight of the year was a world title shot against reigning WBC female super bantamweight champion Fatuma Zarika.
Mercado made a successful seventh defense of her WBC super bantamweight title against Ramla Ali at Footprint Center in Phoenix, Arizona on June 29, 2024, winning by unanimous decision.