On the course of the Long March, the Chinese Red Army used the church to host its political directorate during the Zunyi Conference in January 1935.

According to Adrien Launay [fr], in 1866, the Apostolic Vicar of Guizhou Louis-Simon Faurie [zh] divided his ecclesiastical province into two vicariates, with Zunyi being the seat of the northern one.

[2] In the same year, the French priest Simon-Jude-Alphonse Mihières purchased lands and houses for a location to host worship.

[6] In 1874, the French priest Eugène-Charles Bouchard purchased a local house and founded a church in Zunyi.

In particular, when the army occupied Zunyi several times in 1935, Catholic missionaries had to flee to local Christian families or into the mountains.

[15] At the church, the political directorate convened a town hall with representatives from the local people[16] and a meeting that delivered the resolutions of the Zunyi Conference to Red Army officers.

The church was given to the government in exchange of houses of the same size in the Sifangtai (四方台) area of the city, and the Catholic congregation moved in 1952.

[13] China's National Cultural Heritage Administration (NCHA) funded the church building's renovation in 1978.