Yaqub al-Ghusayn (Arabic: يعقوب الغصين, Ya‘qoub al Ghussein) (1899–1948) was a Palestinian landowner from Ramla and the founder of the Youth Congress Party.

He worked as an inspector at a railway station until the British Mandate, before moving to the field of business and agriculture.

[1] He was married to Thuriya Nuseibeh, also a Palestinian noble, and they had 11 children; Talat, Khaled, Abdel-Kareem, Tawfiq, Aida, Khalida, Heya, Motia’a, Khadija, Nuzha and Fatoum.

On 1 October of the same year he was exiled by the British to the Seychelles Islands for being a member of the Arab Higher Committee.

[citation needed] He was also a member of the Palestinian delegation to the London Conference at St. James's Palace in February 1939.