Yarbro is an unincorporated community in Mississippi County, Arkansas, United States.

[2] A Route 61 overpass across St. Louis–San Francisco Railway track was built by the Bureau of Public Roads in 1939, and was listed on the National Register of Historic Places in 2022.

When a post office opened in the community on March 22, 1900, the town was officially named Yarbro, after a local settler family.

By 1912, the town was home to three general merchandise and grocery stores, a post office, a barbershop, a restaurant, a pool hall, a train station, a blacksmith shop, a boarding house, a stave mill, a Methodist church, a school, two gins, and a bank.

[6] Home to a two-room schoolhouse, Yarbro became part of the Blytheville School District in 1942.