[4] After graduating from high school, he served as a first sergeant in Israeli military intelligence (1979–1982) and then earned a Bachelor of Science in civil engineering in 1986 from the Technion – Israel Institute of Technology in Haifa.

In 2000, he left Santa Clara University to succeed Michael Berliner as President and Executive Director of the Ayn Rand Institute, which was then located in Marina del Rey, California.

In a January 7, 2007, editorial in USA Today, he defended multimillion-dollar CEO pay packages against the attempt by the government to regulate them.

"[11] Brook is co-author, with Don Watkins, of the book Equal is Unfair: America's Misguided Fight Against Income Inequality.

"[14] In 2018, a public event featuring Brook and Carl Benjamin, a controversial YouTuber known as "Sargon of Akkad", as speakers was protested by masked activists.