Ye Lwin, along with his wife, established a private eye clinic on the western outskirts of Mandalay.

Initially facing opposition from the city's residents upon assuming the role of mayor, he later demonstrated his dedication through hard work.

In the aftermath of the 2021 Myanmar coup d'état, he was arrested along with state leaders and ministers and released on February 1.

However, he was detained again on February 9, with authorities claiming that he had incited municipal employees to participate in civil disobedience movements through his social media.

[6][7] Following that, on February 3, 2023, he received another two-year prison sentence on the charge of Section 409 for the misappropriation of state property.