She was married to Andrey of Staritsa, the younger brother of Vasili III and an uncle of Ivan IV.

[4] In response, she herself kept the seal and control of the family principality and refused to give it to her son even as he was no longer a minor.

When recovered, Ivan IV himself had Vladimir include a promise in his oath not to protect his mother if she was to "plan harm" against him again.

In 1563, Yefrosinya was arrested and put on trial for alleged conspiracy and sentenced to live in a convent.

In 1569, Ivan IV again suspected Vladimir to be the object of plots to place him on the throne, orchestrated by his mother: he gave orders that she be executed, which was performed.