Yemassee (/ˈjɛməsiː/) is a small Lowcountry town in Beaufort and Hampton counties in the U.S. state of South Carolina.

As defined by the U.S. Census Bureau, the Beaufort County portion of Yemassee is included within the Hilton Head Island-Bluffton-Beaufort, SC Metropolitan Statistical Area.

Yemassee hosts one of the few commercial breeding facilities of non-human primates in the entire United States, Alpha Genesis, Inc., which serves as a major employer for the town.

Also, the Frank Lloyd Wright-designed Auldbrass Plantation house and outbuildings lie just outside the town limits of Yemassee.

The Yemassee Train Depot was the final stop for Marine Corps Recruits to Parris Island for much of the 19th and 20th centuries.

[6] According to the United States Census Bureau, the town has a total area of 4.5 square miles (11.7 km2), all land.

The town is also home to an Amtrak station, which serves as the principal rail access point for the Lowcountry region.