The ground-breaking of the Opera Theatre took place on 28 November 1930 on the occasion of the 10th anniversary of Soviet Armenia.

Based on Tamanian's design and under the supervision of his son the theatre hall was completed in 1939, and the opera building was named after Alexander Spendiaryan.

Over the years, these artists have worked at the theatre: singers Gohar Gasparyan, Tatevik Sazandaryan, Mihran Yerkat, Pavel Lisitsian, Haykanoush Danielyan, Nar Hovhannisyan, Gegham Grigoryan, Anahit Mekhitarian; conductors Konstantin Sarajev, Michael Tavrizyan, Aram Katanyan, Karen Durgaryan, Gianluca Marciano, Yuri Davtyan; ballet masters A. Petrosyan, M. Chmshkyan, Vanoush Khanamirian, Vilen Galstyan, Rudolf Kharatyan; painters Martiros Saryan, Minas Avetisyan.

The theatre company has performed in more than 20 countries, for example, in Russia, Spain, Lebanon, United States, Greece, and Germany.

The theatre has also hosted concerts performed by Charles Aznavour, Ian Anderson, John McLaughlin, Akvarium and many others.