In 1933, Zeisel moved to Haifa, and began work as an electrician for the Israel Electric Corporation.

Due to the illness of then-mayor Moshe Flimann, Zeisel was appointed substitute mayor.

With Flimann's subsequent death, Zeisel remained in office, and served in that capacity until the election of Yosef Almogi in 1974.

Almog's term didn't last long: in 1975 he was chosen to be the chairman of the Jewish Agency and the Histadrut.

In 1979, Zeisel was chosen to serve as the head of the secondary council of Kiriyat Chaim; he held that post until the day he died.