They had two children: Aharon Rokeach, who would assume the mantle of leadership of the Belz Hasidim after his father's death, and Chana Rochel, who married Pinchos Twerski of Ustila.

After his first wife died, Yissachar Dov remarried Chaya Devora, daughter of Rabbi Avrohom Shmuel Pytshnik of Berezna.

Following his father's death in 1894, Yissachar Dov acceded to the positions of Rav of the town of Belz and spiritual leader of the Belzer Hasidim.

He was an acknowledged leader of Galician Jewry and was renowned as a miracle worker,[citation needed] attracting thousands who sought his blessing.

He created the yoshvim program in Belz which encouraged married and unmarried men to spend all day learning Torah in local shtieblach.