Yitshak Kreiss (Hebrew: יצחק קרייס; born 1965) is an Israeli physician and Director General of Sheba Medical Center in Tel Hashomer.

[5] Kreiss established an IDF combat casualty care plan called "My Brother's Keeper" successfully put into practice during Operation Protective Edge.

[9] He is one of the heads of the MBA healthcare innovation program of the Herzliya Interdisciplinary Center[10] and serves as a visiting professor in the Faculty of Business Administration of Florida Atlantic University.

[1] In 2018, Kreiss signed the "City of Health" agreement, making Sheba Medical Center the recipient of the largest development budget ever awarded to a public hospital in Israel.

[14] From the earliest days of the COVID-19 pandemic, Kreiss was at the forefront of the Israel's emergency response, with Sheba Medical Center opening the first coronavirus ward in the country.

Under Kreiss's direction, a new intensive care unit with hundreds of beds was inaugurated to serve Israel in times of national emergencies.

[15][16] In 2013, Kreiss was the recipient of the Dr. Jean Mayer Global Citizenship Award, granted in appreciation of his humanitarian relief efforts in times of war and peace.