Blasters was originally released in two versions, named Red Cat Corps[b] and White Dog Squad.

[1] Human characters are noticeably absent from gameplay, and players control yōkai in a beat 'em up action style instead.

[2] However, due to copyright and licensing issues, the International releases were renamed, and most of the overt references to Ghostbusters were removed (including notable spoofs of the Ectomobile and Stay Puft Marshmallow Man, among others).

Each Big Boss Mission has a selectable difficulty level: Normal, Super, and Ultra mode.

Additionally, each Yo-kai has a special, powerful move called a Soultimate, which is only performable after the Soul Meter is charged by using attacks.

Equipment sometimes has additional benefits, such as increased critical hit chance or resistance to elemental attacks.

Players are able to create or strengthen equipment, which usually requires materials and Oni Orbs, and occasionally Yo-kai Souls.

Players can also gain equipment by scanning special QR codes, or as treasure drops after clearing a mission.

Players can perform Soulcery to turn Yo-kai into an equippable items called Souls that grant certain benefits.

[4][5] A sequel, Yo-kai Watch Busters 2: Secret of the Legendary Treasure Bambalaya,[f] was also released in two versions, Sword[g] and Magnum,[h] on December 16, 2017.