Yodo-juku (淀宿, Yodo-juku) was the second station on the Ōsaka Kaidō (or fifty-fifth of the fifty-seven stations of the Tōkaidō).
It is located in the southern part of Fushimi-ku in the present-day city of Kyoto, Kyoto Prefecture, Japan.
Located between the Yodo and Katsura rivers, Yodo-juku was founded in 1619.
During the Edo period, it was part of the castle town that surrounded Yodo Castle, which was constructed in 1623.