Yonekura Masanori was born as the 9th son of Mizuno Kadakane, daimyō of Karatsu Domain in Hizen Province.
In January 1803, he was adopted to be heir to the 5th daimyō of Mutsuura Domain (Yonekura Masayoshi), and was confirmed to that position in an audience with Shōgun Tokugawa Ienari in March of the same year.
Yonekura Masayoshi then claimed illness, and retired on June 15, surrendering his title and official positions.
As daimyō, Masanori was assigned to several ceremonial postings as guard of various gates to Edo Castle.
In August 1811, he was dismissed from his post as magistrate in Osaka for incompetence, and died of a sudden illness on April 18, 1812.