The Yonesaka Line (米坂線, Yonesaka-sen) is a railway line in Japan, operated by East Japan Railway Company (JR East).

At Yonezawa, connections to the Yamagata Shinkansen and Ōu Main Line can be made; while the Uetsu Main Line connects at Sakamachi Station.

The line takes its name from the first kanji of Yonezawa (米沢) and Sakamachi (坂町).

Trains can only pass each other at Uzen-Komatsu, Imaizumi, Uzen-Tsubaki, Oguni, Echigo-Kanamaru, and Echigo-Shimoseki stations.

Symbols: As of April 2020[update], the following rolling stock is used on the Yonesaka Line.