Cerebral palsy is a serious motor disorder which frequently appears in preterm newborn babies, and has been traditionally linked to hypoxic obstetric events.

From 1996, Yoon and his colleagues provided strong clinical and experimental evidence that intrauterine infection/inflammation, which is causally linked to preterm birth, plays an important role in the pathogenesis of fetal brain damage and cerebral palsy.

Moreover, they demonstrated that intrauterine infection/inflammation is an important risk factor for the development of bronchopulmonary dysplasia which is one of the most frequent and significant complications of preterm newborns.

Over the last twenty years, Yoon and his colleagues have published a number of important articles in the area of preterm births, intra-amniotic infection/inflammation and fetal damage.

For example, The outcomes of preterm neonates who were born in Seoul National University Hospital have been improved noticeably since they actively diagnosed and treated intrauterine infection with new regimen of antibiotics they developed.