It is managed by York and Scarborough Teaching Hospitals NHS Foundation Trust, an NHS Foundation Trust which also runs several other hospitals in North Yorkshire and the East Riding of Yorkshire, including Scarborough Hospital, Bridlington Hospital and Malton Community Hospital.

[1] It was officially opened by Princess Alexandra on 28 July 1977.

[1] There is an Accident and Emergency department at York Hospital which is open every day.

[2] The hospital provides acute medical and surgical services for York and the surrounding areas.

[2] York Hospital was rated as Requires Improvement by the Care Quality Commission in March 2023.